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Biomarkers in the diagnosis of canine heart disease
http://www.ivis.org/journals/vetfocus/18_3/en/1.pdf

So I went to the vet today to pull blood for Chase's T4, wellness, and heart worm. We were discussing heart disease and I mentioned that I'm looking for a holter to rent out this year for him. The vet asked me if I knew anything about Cardiopet proBNP.

Apparently it has a more sensitivity and specificity for detection of occult disease than a holter or echo.

I'm still researching on this diagnostic tool, but for $50 as an add on, I couldn't say no to testing Chase. Results will be in tomorrow morning.

Does anyone else know about this?
 

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Had not heard of it until now... Just read up on the research and looks great! Obviously they need a larger pool of research candidates to confirm those percentages, but as far as the chemistry/bio behind it, I feel that the percentages are probably fairly accurate!

I will definitely be asking my vet about it!
 

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Holier Than Now
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I get mine done, too, annually.

I don't know about it being "more sensitive" than holter/echo, but I do consider it an added way to possibly catch something early.
 

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Interesting! Thanks for linking that up. I had never heard of it before, and will now be asking for it when the time comes for our cardio testing routine to begin :)
 
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Pro BNP heart test

I posted about it 12/29/2008 under the title above. Did you get the results of Nancy Morris's bnp study?
 

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Eat Poo and Die
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We talked about it with our cardiologist and while echos/holters are our main thing, if his echo in august/sept. is still borderline, we will do a BNP to see if that pushes the numbers either way. He explained it well, but I completely forgot it. It was something about balances, and when something is out of balance, it can show through the test, but you can also get false positives. And that is why we don't use it as a primary test, but rather as just something else to help us consider the progression of his disease and where we are and when we should begin medicating.
 

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So I am a vet assistant and Did the Pro BNP CardioPet- IDEXX the results are 2,955 - what is Ideal is usually around <900. So I kind of am freaking out. One of my vets said just to holter, ECG,and EKG him at the Next show as its about almost half of what I will have the same Cardiologist do in May at the dog show. What I am concerned about is that Should I wait? Would doing the Vet Gen DCM DNA PDK4 test be of any benefit? and should I be concerned now and be doing tests now. It's like $250.00 with my discount for me to do a ECG by my regular Drs. that are Not Cardiologist. , One of my vets did tell me that the Main Radiologist in the area doesn't like that the ProBNP test and doesn't recommend it. He doesn't think relevant information from this test is always conclusive towards heart failure.
Has anyone had any experiences with this test and high results and if those high results correlated to high risk or already in heart failure. I have so many questions and I can't wait to talk to my vets more in the morning. Titan will be 9 years old May 14th and comes from known lines with lots of health problems.

Any answers are greatly appreciated.

This is my first Dobermann ever, my female just turned 5 yesterday, she is DNA DCM NEGATIVE -VetGen, (Holter monitored, 09, 2012,) (ECG, 2011, 2012) always Normal, 0 VPCs.

Titan is in Good health, 9 years old neutered male, VWD AFFECTED, Thyroid normal ( Will be running a full panel this week.) He was neutered at 3 years old and never sired any litters. I had a physical wellness exam done by my boss,/Vet. He said his heart Sounded Good. I told him my concerns on his heart as he is getting up there and thats what happens to many of our Purebred friends, especially dobes. So I ran the panel just as a precautionary as I Pay 50% on some blood work as an employee.

What panels do you guys recommend. Because asking other people with Dobermans are the answers I'd like to hear, as my Veterinarians are not Doberman specialists and mainly look at things from a medical stand point, especially because He does not breed dogs.
 

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sufferin succotash
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Sam's BNP tests have always been fine. However, I don't use this test as the sole means for cardio screening. I do holter, Echo and EKG him.

The PDK4 test, well, I wouldn't rely on that just yet. There are known instances of negative tests of DCM dogs. It doesn't hurt to test but there are still many unknowns.

Personally, I prefer to use a cardiologist for Sam's cardio testing. They have the skill set and specialty in this field. My regular vet is good but isn't a cardio specialist.

I think you should get him holtered as it provides cardio activity over a 24 hour period.
 

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So I am a vet assistant and Did the Pro BNP CardioPet- IDEXX the results are 2,955 - what is Ideal is usually around <900. So I kind of am freaking out. One of my vets said just to holter, ECG,and EKG him at the Next show as its about almost half of what I will have the same Cardiologist do in May at the dog show. What I am concerned about is that Should I wait? Would doing the Vet Gen DCM DNA PDK4 test be of any benefit? and should I be concerned now and be doing tests now. It's like $250.00 with my discount for me to do a ECG by my regular Drs. that are Not Cardiologist. , One of my vets did tell me that the Main Radiologist in the area doesn't like that the ProBNP test and doesn't recommend it. He doesn't think relevant information from this test is always conclusive towards heart failure.
Has anyone had any experiences with this test and high results and if those high results correlated to high risk or already in heart failure. I have so many questions and I can't wait to talk to my vets more in the morning. Titan will be 9 years old May 14th and comes from known lines with lots of health problems.

Any answers are greatly appreciated.

This is my first Dobermann ever, my female just turned 5 yesterday, she is DNA DCM NEGATIVE -VetGen, (Holter monitored, 09, 2012,) (ECG, 2011, 2012) always Normal, 0 VPCs.

Titan is in Good health, 9 years old neutered male, VWD AFFECTED, Thyroid normal ( Will be running a full panel this week.) He was neutered at 3 years old and never sired any litters. I had a physical wellness exam done by my boss,/Vet. He said his heart Sounded Good. I told him my concerns on his heart as he is getting up there and thats what happens to many of our Purebred friends, especially dobes. So I ran the panel just as a precautionary as I Pay 50% on some blood work as an employee.

What panels do you guys recommend. Because asking other people with Dobermans are the answers I'd like to hear, as my Veterinarians are not Doberman specialists and mainly look at things from a medical stand point, especially because He does not breed dogs.
Sorry, I got a bit confused, reading your post (I can hear your freak-out, sorry!).

Do you mean you will have the opportunity to holter/echo him in a couple more weeks, this coming May?

If so, and he's not showing arrhythmias on an EKG, then I'd likely wait, myself--but I'd also likely consult a cardiologist about whether it's appropriate to wait or not.

I think the question I usually find myself asking myself (great English, huh?) is this: Will the results of these tests change the course of this disease, or the treatment protocol in any way?

And: Will my dog be in any increased discomfort/greater risk if I wait?

If the answer to both of those is "NO," then I tend to go with the vet's recommendation to wait.

I would be concerned with bnp results that out-of-whack, but keep in mind it's a measure of inflammation, and doesn't have to mean he's actively in heart failure at this point.

I also ran tick panels once, when I had a dog come back fairly high, just to rule that out. I have an agility pal with a Weim who had all sorts of crazy bloodwork results and arrhythmias when she had Rocky Mtn Spotted Fever. Just something else to run by your vets.

I hope you get good results and this turns out to be an unnecessary freak-out.
 
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Chase's results came back, I think it was 150, definitely below 200. I'll be getting the hard copies next week. So it sounds like from the bloodwork he is very healthy, which is awesome news since he is from unknown bloodlines and he is almost 4 years old.

Still trying to contact Guelph, and private breeders to rent out a holter this year.
 

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RFR, lol yes I am freaking out. But the Dr. Said his heart sounded great, Theres a dog show I'm going to in the end of May that I will holter, ECG,EKG him there if there isn't any signs of discomfort, coughing etc. before than. I'm going to call my cardiologist to ask if its ok to wait or if I should get him in now. thanks
 

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My dogs have been getting the IDEXX Pro BNP test for a few years now. Especially, my older male who has since passed.

Recently (late March) I had my current male in to our cardiologist to get a good baseline of his heart with the echo, holter, a significant blood work up with liver values and the Pro BNP. His levels were 126. This test is never used by my cardiologist on it's own. One of the things noted on the bottom of the test I receive for each of my dogs is this:

"Therapeutic decisions should be based on results of a cardiac work up. NTproBNP concentrations may decrease with cardiac medication. Arrythmias and the presence of pulmonary hypertension may result in higher NTproBNP concentrations. Azotemic dogs may have increased NTproBNP concentrations."

Which tells me that this is only one test that can be used in the puzzle and thus isn't the most accurate way to determine treatment.

I'd wait to be able to attend the holter/echo clinic at the discounted rate. You can always have the results forwarded to your usual cardiologist for review.
 

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Luckily the clinic is being done by my preferred Cardiologist anyways. I'd go to her even if I didn't have a discount. So I talked and researched alot about this and problems associated with high ProBNP Nt-. I'm Holtering, ECG,and EKG'ing both my altered dogs the end of may at a dog show I'll be doing Rally and OB with my girl. What is your preferred method of treating early cardiac symptoms. Does anyone feed Hill's science Dient H/D or G/D for Cardiac Health? I personally feed grain free as my male doesn't tolerate many foods without major skin problems, baldness and itchiness.

My boss recommended I start him on Vetmedin. I know its expensive and I don;t get a very good discount on Medications.
 

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So my male is in Moderate Heart failure- DCM, at 9 years old. He was never bred because he is vWD affected So I neutered him. I got him when I was 14 years old I am so sad I can't begin to explain. I've never had a dog die of anything but old age or accidents before. My two chows had and 1 has cancer now but they are 12-13 years old. So I am so sad. But at least I know now. My female Baby Belona Von Gruosi- 5 years old heart went awesome, and she is PDK4 Negative 0 copies, so that was good. :(
 
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