I would try a good amount of exercise before your trip and take along a favorite toy or bone. When we travel on long trips we do not feed Titus (Jada has not taken a long trip yet) until we get to our destination. We are in Florida and usually take a trip once a year to TN to see my husbands parents. Sure would not want Titus to get sick in the mountains. He is usually pretty unsettled for about 30 minutes but when he figures out that it is not an early trip to the DP he sleeps most of the 10 hour trip. Good luck and have a safe trip