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post #1 of 28 (permalink) Old 06-09-2010, 05:04 PM Thread Starter
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Important Research Study-dna needed

This came in via email from DPCA:


June 8, 2010




IMPORTANT RESEARCH STUDY FOR DOBERMANS



Samples from Dobermans diagnosed with cancer, cardiomyopathy and/or wobblers are needed NOW for a new, well funded research program pursuing genetic markers for these diseases. There is NO COST to owners for submitting samples and ALL SAMPLES WILL REMAIN COMPLETELY ANONYMOUS.

The past year has witnessed remarkable advances in canine genetics including the launch of new molecular tools for elucidating the complete genetic code of an individual dog. Scientists at the Translational Genomics Research Institute (TGen), in collaboration with those at the Van Andel Research Institute (VARI), are employing these advances to accelerate research into the basis of devastating diseases affecting both canines and humans.

There is presently seven figure funding, technological infrastructure and collective expertise to enable the rapid completion of canine genetic research projects in a matter of months as opposed to years. TGen/VARI have requested samples to pursue study of Doberman breed associated 1) cancer, 2) cardiomyopathy and 3) wobblers. IF sufficient numbers of DNA samples from affected Dobermans are received, initial results of research may be reported as early as at this year's National.

***You will be mailed a saliva collection kit free of charge to whatever address you indicate. The kit will include a postage pre-paid envelope for you to return the sample in. The saliva collection process takes less than 3 minutes, is painless, and can be done in the privacy of your own home- no vet visit/trip required.***

For EACH of these 3 conditions a minimum of 40 samples are needed- that is 40 Dobermans diagnosed with each disease. If the Institutes receive 40 or more samples from Dobermans with each condition, they will use them to pursue scientific evaluation of the underlying biology and genetic bases of these diseases. **At this time in our established Doberman DNA blood bank, there are only 2 dogs reporting wobblers and 7 reporting DCM. THUS, THIS OPPORTUNE, WELL FUNDED RESEARCH CAN ONLY BE UNDERTAKEN IF MANY MORE SAMPLES FROM DOGS DIAGNOSED W/ EACH DISEASE ARE SUBMITTED.**

For each of the following types of cancer, 10 affected Dobermans each are needed to submit samples: lymphoma, osteosarcoma, hemangiosarcoma, melanoma and malignant histiocystosis.

This is an unprecedented opportunity for the Doberman Pinscher community to step up and help researchers address major health problems in our breed. Dr. Mark Neff (TGen/VARI) is on schedule to speak this October at National. He indicates he would be particularly enthused if he could present some successful findings on one or more breed associated diseases at that time.

We all KNOW there are more than 40 Dobermans afflicted with each of these diseases out there. The greater the number of specimens received, the greater the accuracy of research findings.

Please let's avail ourselves of these cutting edge research programs toward improving the health of our breed- the funds will not be there forever! PLEASE, take a few minutes to participate *For the Love of Dobermans*!!




For saliva submission kits (+/- info. on submitting blood), please contact with the number of kits you need, your mailing address and phone:
DNA Collections c/o Elissa Boguslawski
[email protected]
616-234-5561




Please contact me with any questions.


Thank you very much,
Kathy Davieds DVM [email protected]





Clarifications:

1. Occult OR actual clinically affected DCM dogs are both needed, simply note which stage your dog is in on the form they send you.

2. If you already donated your dog's blood to the DNA blood bank but at that time your dog was not diagnosed with any of these diseases but now is, you need to contact Eddie Dzuik with OFA (that maintains the samples/info.) at [email protected] and update that information. If this
is the case, I'd also suggest contacting Elissa and letting her know you've done this w/ your dog's previously banked blood so she will know to access your dog's blood sample for this research. Because there are so many dogs in the DNA blood bank not reported as diagnosed with any of these conditions, AT THIS TIME the researchers do not need samples from *healthy*
dogs. If that changes in the future I will certainly post.

Thank you to EVERYONE for submitting samples!!! This sure is a no brainer, free, painless,
confidential, and highly motivated researchers with excellent funding, interested in several Doberman diseases!


PS:
1. Blood samples are also very desirable from dogs diagnosed with any of the above conditions (desirable but not required). If you are willing to take the extra step of providing a blood sample from your dog, the Institutes will reimburse your veterinarian $10 for the blood draw procedure AND provide you with a FedEx account number to completely cover the cost of shipping the sample in. Simply indicate when you contact Elissa that you need the info. on how to submit a blood sample.

2. Dogs diagnosed with more than one of these diseases ARE eligible to participate; owners should simply note this on the submission form. Also, if your dog has other health issues besides these three conditions they too can participate.

IN SUM: ***NO COST
***COMPLETELY CONFIDENTIAL (switched over into code upon receipt at lab)
***SPECIMENS FROM DOBERMANS DIAGNOSED WITH CANCER, DCM (clinical/symptomatic OR occult), WOBBLERS NEEDED NOW!

PLEASE CROSSPOST WIDELY- THIS NEEDS TO REACH EVERY DOBERMAN OWNER POSSIBLE



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post #2 of 28 (permalink) Old 06-09-2010, 10:19 PM
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Yes. A Study for the 3 Big C's. This is awesome news!!!!
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post #3 of 28 (permalink) Old 06-09-2010, 10:33 PM
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I had already contacted her - but it may be even easier, since Rah is already banked with the OFA!!!! So I've contacted the OFA as well to update them fully on his complete diagnosis Need to find out when I can bank Berlin as well...


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post #4 of 28 (permalink) Old 06-10-2010, 09:09 AM
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There is a 4 1/2 month blue female on the Distinguished Doberman Rescue site that has Wobbler's. I believe Dragonflyz volunteers there.

I will also give this post to my vet because she has a large doberman clientele.
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post #5 of 28 (permalink) Old 06-10-2010, 11:18 AM
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I just opened my DPCA email murreydobe....and thought how wonderful to have more research for our babies! Let's pray with all these samples of diagnosed dogs, they are able to pinpoint the dna culprit asap!

Thanks for posting this!

***Maybe have a mod add to the title...samples needed from wobbler, cardio and cancer stricken dogs now!
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post #6 of 28 (permalink) Old 06-10-2010, 12:27 PM
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I don't suppose they could use hair samples from deceased dogs, could they?




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post #7 of 28 (permalink) Old 06-10-2010, 12:34 PM
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Sounds like they need saliva and/or blood samples.

Isn't there someone here who had an osteo girl leg amputation recently? (brain freeze on her name.)
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post #8 of 28 (permalink) Old 06-10-2010, 02:11 PM
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Quote:
Originally Posted by ellenm View Post
Sounds like they need saliva and/or blood samples.

Isn't there someone here who had an osteo girl leg amputation recently? (brain freeze on her name.)
EmilyB
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post #9 of 28 (permalink) Old 06-10-2010, 02:33 PM
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Sticky please.
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post #10 of 28 (permalink) Old 06-10-2010, 02:48 PM
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Quote:
Originally Posted by wantsaDobe View Post
Sticky please.
Great Idea!
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post #11 of 28 (permalink) Old 06-10-2010, 03:52 PM
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Just to clarify, I'm not sure why the OFA database is brought up in the original post, because she does NOT want to access this database and wants her own collection of DNA, so while I have already updated OFA with the diseases that my dog they have banked is afflicted with, she will still want her own separate sampling taken.


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post #12 of 28 (permalink) Old 06-16-2010, 08:55 AM
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Quote:
Originally Posted by doberkim View Post
I had already contacted her - but it may be even easier, since Rah is already banked with the OFA!!!! So I've contacted the OFA as well to update them fully on his complete diagnosis Need to find out when I can bank Berlin as well...
Has anyone that has contacted the study received a response? I had emailed her on 6/10/2010 and have not heard a response.

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post #13 of 28 (permalink) Old 06-16-2010, 03:06 PM
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Yes, I emailed her and got a few responses. I'm currently waiting for my kit - as are some other people I know. If you haven't gotten a response, I'd email again.


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post #14 of 28 (permalink) Old 06-27-2010, 08:04 PM Thread Starter
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Here's an update email. Note that they've opened research to add a fourth disease, so now need 40 dna samples from dobermans who've been diagnosed with liver disease. Since Razzle falls into that liver disease category, I'll be contacting them tomorrow to get a sample kit, so we can do our bit.

---------------------------------------------------

Doberman owners rock! *We are very impressed with Doberman owners,* say researchers at the Institutes who report there have been many requests for sample submission kits and samples are coming in almost daily. (And, quite a number of people have volunteered that they *don't need confidentiality* for their specimens/identity.)

Here are some important updates to the recent call for saliva/blood samples for DNA research on Doberman diseases.

1. A fourth breed associated condition has been included for DNA research if sufficient specimens are received. 40 samples (saliva, or blood *if* owners are able) from dogs afflicted with Doberman liver disease are needed to undertake DNA evaluation of this disease. It is hoped that Dobe owners will be as forthcoming for this condition as they are being for DCM, wobblers and cancer.

2. Some have asked if there is a cutoff date for sample submission. While there is no cutoff date at this time, the researchers are extremely eager to have DNA evaluation of these 4 breed associated conditions underway. In fact, they are hoping to be able to have at least some preliminary results as early as August, and definitely before National. In order to do this, they must receive the needed number of samples very soon. The faster we get Doberman samples in to them, the faster research can progress. So please contact them TODAY to request your free submission kit. Please collect your sample(s) and get them on their way to the Institutes ASAP!

Once I learn the number of samples already received for each disease I will report that information. In the meantime remember, YOUR dog's sample is important. Also, the greater the number of samples, the greater the accuracy of research results. Lastly, keep in mind- the funding (your taxpayer dollars at work) is presently there for this research- once it is used and gone, it is gone. So let's please avail ourselves of this wonderful opportunity to help our breed, now!

3. Re: samples from DOGS WITH CANCER, there is a new development. Many dogs of many breeds are affected by lymphoma and osteosarcoma but *relatively* fewer suffer from MELANOMA. In order for a dog breed to be selected as a model for study of a particular type of cancer, thus to *go to the top of the line in terms of study*, a minimum of 25 saliva samples (or blood *if* possible) from affected dogs of that breed are needed. We are already on our way to the original 10 sample requested. Eligible dogs can have malignant or benign melanoma, and they can have had melanoma in the past but been successfully treated for same and not presently have cancer. If your Doberman has or ever has had melanoma, Please submit a sample on him or her now.

4. Many Dobe owners whose dogs donated blood in the past to our DNA blood bank have already been in touch w/ Mr. Dziuk w/ OFA as requested to update their donor dog's health status. He asks that anyone who has not yet done so, please contact him now at [email protected] Thank you.

For saliva submission kits (+/- info. on submitting blood) for Dobermans with cancer, DCM, wobblers or Doberman liver disease, please contact with the number of kits you need, your mailing address and phone:

DNA Collections c/o Elissa Boguslawski

[email protected]

616-234-5561



Please contact me with any questions. Thank you very much,

Kathy Davieds DVM


Remember:
1. Blood samples are also very desirable from dogs diagnosed with any of the above conditions (desirable but not required). If you are willing to take the extra step of providing a blood sample from your dog, the Institutes will reimburse your veterinarian $10 for the blood draw procedure AND provide you with a FedEx account number to completely cover the cost of shipping the sample in. Simply indicate when you contact Elissa that you need the info. on how to submit a blood sample.

2. Dogs diagnosed with more than one of these diseases ARE eligible to participate; owners should simply note this on the submission form. Also, if your dog has other health issues besides these three conditions they too can participate.


***NO COST

***COMPLETELY CONFIDENTIAL (switched over into code upon receipt at lab)


***PLEASE CROSSPOST***


_______________________________________________



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post #15 of 28 (permalink) Old 06-27-2010, 08:20 PM
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Just seeing this today.....I will do it too.

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post #16 of 28 (permalink) Old 06-27-2010, 09:59 PM
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Rah's sample went in the mail this past week!


Bowie's Here Comes the Boom! UD BN RN TKP WAC CGC
Katwalk Calm Like a Bomb UDX OM1 PCD GN BN TKP CD-C CGC
Bowie's Atomic Bomb NW1 TKI
ARCHX Bowie's Semper Fidelis v DRU, UD ASCA-CDX CDX-H D-CD RE RL1X RL2X RL3 ATT WAC TT CGC VC FFX-OG
Beja's Bombs Away v Bowie, CD ASCA-CD CD-H BN RN NA NAJ RL1 WAC ATT YTT PTT CGC CHIC#71265
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post #17 of 28 (permalink) Old 06-28-2010, 12:03 AM
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My osteo dog Priscilla is in Canada, usually that is a problem....sigh...but I will contact her.
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post #18 of 28 (permalink) Old 06-28-2010, 10:11 AM Thread Starter
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Just talked to Elissa on the phone-she's sending kits to me this week for Razzle (CAH) and Connor, who's going to be a control dog.

I'm going to send a link to this message to Dragonman, whose boy Drago also has liver disease. I think we have at least one other person on this board whose dog has CAH, I hope they also will participate, as will anyone else whose dog has DCM, CVI, or cancer.




Last edited by Murreydobe; 06-28-2010 at 10:18 AM.
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post #19 of 28 (permalink) Old 07-03-2010, 07:55 AM
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Due to the recent turn of events I plan on calling on tuesday to ask if Miesha would be a good canidate... or if they would want to wait until I get a formal diagnosis from Cornell...

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post #20 of 28 (permalink) Old 07-07-2010, 01:43 AM
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Hmm just saw this. I will call tomorrow about Drago's inclusion in the liver disease trial. He has his DNA at OFA as well but I can get a sample drawn if necessary.

Thanks, Tracy


DRAGONHEART DOBERMANS
Can Ch Dragonheart's Mighty Dragon CGC WAC "Drago"
R.I.P. 09/18/05-04/24/11
Am/Can Ch Starlaine Wild Wild West CGC "Mariah"
Dragonheart 'N Starlaine The Gunslinger "Victor"
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post #21 of 28 (permalink) Old 07-07-2010, 02:11 AM
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Quote:
Originally Posted by Murreydobe View Post
Just talked to Elissa on the phone-she's sending kits to me this week for Razzle (CAH) and Connor, who's going to be a control dog.

I'm going to send a link to this message to Dragonman, whose boy Drago also has liver disease. I think we have at least one other person on this board whose dog has CAH, I hope they also will participate, as will anyone else whose dog has DCM, CVI, or cancer.
I am so excited about this research. My last boy passed of CAH (he was also occult DCM).
The other person that I know of on this board is Dobes4us. I will send her a PM to this thread.


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Life's challenges are not suppose to paralyze you, they are suppose to help you discover who you are ~Bernice Reagon

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Last edited by Dobesanddragons; 07-07-2010 at 02:16 AM.
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post #22 of 28 (permalink) Old 07-07-2010, 06:23 AM
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Originally Posted by txsaphire View Post
There is a 4 1/2 month blue female on the Distinguished Doberman Rescue site that has Wobbler's. I believe Dragonflyz volunteers there.

I will also give this post to my vet because she has a large doberman clientele.
The little Blue Girl has been adopted so we no longer have her, but do they need control dogs? I would be glad to send a kit in from Tango?

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post #23 of 28 (permalink) Old 07-07-2010, 09:56 AM
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They told me they would love to have samples from my dogs - maybe as controls?. I received my package yesterday.


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post #24 of 28 (permalink) Old 07-07-2010, 10:54 AM
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Well Drago has a recheck for his liver disease this morning actually. So I've got the paperwork to submit him with a blood draw today. I'm always happy to help future successful research on doberman health. I hope they find something.


DRAGONHEART DOBERMANS
Can Ch Dragonheart's Mighty Dragon CGC WAC "Drago"
R.I.P. 09/18/05-04/24/11
Am/Can Ch Starlaine Wild Wild West CGC "Mariah"
Dragonheart 'N Starlaine The Gunslinger "Victor"
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post #25 of 28 (permalink) Old 07-07-2010, 11:05 AM Thread Starter
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Well Drago has a recheck for his liver disease this morning actually. So I've got the paperwork to submit him with a blood draw today. I'm always happy to help future successful research on doberman health. I hope they find something.
Great!

My kits are ready for me to take to the PO today.



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