Dcm - Doberman Forum : Doberman Breed Dog Forums
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post #1 of 4 (permalink) Old 07-26-2020, 03:31 PM Thread Starter
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Dcm

Can some explain the following to to me?

DCM1 – Heterozygous
DCM2 – Heterozygous
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post #2 of 4 (permalink) Old 07-26-2020, 03:43 PM
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There are currently two known genes for Dilated Cardiomyopathy in Dobermans, called DCM1 and DCM2. There are three possible test results, homozygous positive (two copies of the gene, or +/+), homozygous negative (no copies of the gene, or -/-), and heterozygous (one copy of the gene, or +/-).

However, since dogs who test negative for both genes can develop DCM, and dogs who test positive for both genes may not develop it at all, knowing the results of these are more for research purposes than anything else at the moment. Breeders still need to do annual holters (24 hour EKG) and echoes (ultrasound) to check the dog's actual heart function.
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post #3 of 4 (permalink) Old 07-26-2020, 07:16 PM Thread Starter
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Really appreciate the quick response and inputs.
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post #4 of 4 (permalink) Old 07-27-2020, 10:53 AM
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My addition to Rosemary's post would be to make sure you understand that the echo and holter is a snapshot in time. Dogs can have a perfect echo and holter and develop DCM within a few months. Studying pedigrees is important for breeders and talking to your breeder about the history of DCM in your (proposed) puppy pedigree is important. How many dogs in the lineage had DCM? At what age was it diagnosed? When did they die?

In addition to that, understand that DCM is in ALL lines of Dobermans. Anyone who says otherwise doesn't know the pedigrees of their dogs well enough. It does certainly vary, and some lines have more than others. But also know that the disease is not understood well enough yet. We simply don't know how it is inherited. You can have long lived dogs that produce DCM young. You can have a dog that died of DCM produce dogs that do not get the disease. This is a very, very complex disease that we do not yet have enough information about to have easy answers on. If you are going to get a Doberman you have to be willing to live with the uncertainty of whether your dog will get it, and when. That doesn't mean you don't research and you don't buy from a breeder that is doing their very best to avoid it, but...that's where we're at.
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