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post #1 of 7 (permalink) Old 05-15-2020, 09:52 PM Thread Starter
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Vwd

Does anyone know much about VWD.

In humans its an autosomal dominant condition for type 1 and 2; type 2 and 3 autosomal recessive...
So if your dog is a carrier should you be concerned ?
Its based on % of factor in the blood really but theoretically can a carrier have a low enough factor where surgery becomes risky ?
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post #2 of 7 (permalink) Old 05-16-2020, 01:45 AM
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In general in canines a carrier would have not much risk of running out of vWD factor.

The exception to that (I've been told by a couple of vet surgeons) would be a situation where the surgery was long and extremely bloody (by which time the animal having the surgery would probably already be receiving transfusions. So it kind of becomes a moot point.

In dogs, from what the clinic I work for has had a PhD geneticist who got bored with microscopes and went back to school and became a vet--she passed along a lot of not real common knowledge about genetic problems and did a short seminar on vWD in dogs a few years ago.

Since we were never comparing it to vWD in humans there may be some wide differences between the human version and the canine version. But in dogs vWD is a classic dominant/recessive genetic issue. The types have to do with the effects (actually I thought is was on different breeds in dogs) Most are going to be type 1--Dobermans are Type 1 and in them even affected vWD dogs are not all that often clinical--which is to say they generally have enough vWD factor to deal with most bleeds because the genes are "leaky" and do produce some vWD factor. Type 2 dogs are mostly in the family of German Wirehaired Pointers. And type 3 dogs are Shelties and (just went blank here--maybe Scotties--you can read the information on VetGen's website about vWD and it lists the various breeds who are Type 1, 2 or 3.

One of the summaries I read speculated that affected dogs are fairly rare in Type 3 breeds and that it's probably because most puppies die in utero and are never whelped.
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post #3 of 7 (permalink) Old 05-16-2020, 11:25 PM
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The short answer is that a VWD carrier is not an issue at all in Dobermans.
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post #4 of 7 (permalink) Old 05-20-2020, 10:24 AM
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Dobebug rather elegantly explained the gist of it.
As Fitzmar stated, in short, vWD carriers in Dobermans are not considered to be a concern, and even those who are genetically affected, while they may need to be monitored, may not ever become clinically affected.
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post #5 of 7 (permalink) Old 06-05-2020, 07:15 AM
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Von Willebrand disease is a serious condition that affects the blood and clotting ability of some dogs. Many dogs live a very normal life and owners don't even know their dog has a clotting problem until a blood draw, surgery, or injury occurs. By knowing what to look for, how to diagnose von Willebrand disease, and the precautions that can be taken to keep a dog with a clotting disorder safe, you can help prevent unnecessary bleeding problems.

The above from a veterinary web site

Dobes are listed as one of the species likely to have it. Biggest problem is with breeding, if both parents are carriers the puppies will have serious problem.

A brief explanation, Von Willebrand disease leads to a shortage of Factor VIII in the clotting cascade that is triggered by an injury. It can be managed, if not to severe, by infusing the missing proteins into the blood. I do not know if such supplements are available for dogs but there are other methods of controlling the bleeding
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post #6 of 7 (permalink) Old 06-05-2020, 08:23 AM
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Quote:
Originally Posted by Phy View Post
Von Willebrand disease is a serious condition that affects the blood and clotting ability of some dogs. Many dogs live a very normal life and owners don't even know their dog has a clotting problem until a blood draw, surgery, or injury occurs. By knowing what to look for, how to diagnose von Willebrand disease, and the precautions that can be taken to keep a dog with a clotting disorder safe, you can help prevent unnecessary bleeding problems.

The above from a veterinary web site

Dobes are listed as one of the species likely to have it. Biggest problem is with breeding, if both parents are carriers the puppies will have serious problem.

A brief explanation, Von Willebrand disease leads to a shortage of Factor VIII in the clotting cascade that is triggered by an injury. It can be managed, if not to severe, by infusing the missing proteins into the blood. I do not know if such supplements are available for dogs but there are other methods of controlling the bleeding
That's not necessarily true. If both parents are carriers, offspring will statistically be 25% affected, 50% carrier, 25% clear... that's simple genetics. More importantly though, an affected dog or bitch is likely to live a completely normal life with no clinical signs. If you know your dog is affected (and any good breeder will test puppies in a litter that may produce affecteds) it is very strongly recommended that you take extra precautions like doing pre-op bloodwork and have blood on hand for any surgery in case of a serious complication. JMO there are far worse things than Vwd in our breed.
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post #7 of 7 (permalink) Old 06-05-2020, 09:34 AM
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My male has an affected puppy on the ground from a carrier to carrier breeding. Zero issues during tail docking and ear cropping. The breeder has owned 2 affected dobes from carrier to carrier breeding's, one lived until 13 and the other until 14, zero bleeding issues whatsoever.

I'll also add the vWD is not a serious disease when one knows what they're doing and supports a reputable breeder who also knows what they're doing.
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