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post #1 of 4 (permalink) Old 05-15-2020, 09:52 PM Thread Starter
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Vwd

Does anyone know much about VWD.

In humans its an autosomal dominant condition for type 1 and 2; type 2 and 3 autosomal recessive...
So if your dog is a carrier should you be concerned ?
Its based on % of factor in the blood really but theoretically can a carrier have a low enough factor where surgery becomes risky ?
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post #2 of 4 (permalink) Old 05-16-2020, 01:45 AM
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In general in canines a carrier would have not much risk of running out of vWD factor.

The exception to that (I've been told by a couple of vet surgeons) would be a situation where the surgery was long and extremely bloody (by which time the animal having the surgery would probably already be receiving transfusions. So it kind of becomes a moot point.

In dogs, from what the clinic I work for has had a PhD geneticist who got bored with microscopes and went back to school and became a vet--she passed along a lot of not real common knowledge about genetic problems and did a short seminar on vWD in dogs a few years ago.

Since we were never comparing it to vWD in humans there may be some wide differences between the human version and the canine version. But in dogs vWD is a classic dominant/recessive genetic issue. The types have to do with the effects (actually I thought is was on different breeds in dogs) Most are going to be type 1--Dobermans are Type 1 and in them even affected vWD dogs are not all that often clinical--which is to say they generally have enough vWD factor to deal with most bleeds because the genes are "leaky" and do produce some vWD factor. Type 2 dogs are mostly in the family of German Wirehaired Pointers. And type 3 dogs are Shelties and (just went blank here--maybe Scotties--you can read the information on VetGen's website about vWD and it lists the various breeds who are Type 1, 2 or 3.

One of the summaries I read speculated that affected dogs are fairly rare in Type 3 breeds and that it's probably because most puppies die in utero and are never whelped.
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post #3 of 4 (permalink) Old 05-16-2020, 11:25 PM
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The short answer is that a VWD carrier is not an issue at all in Dobermans.
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post #4 of 4 (permalink) Old 05-20-2020, 10:24 AM
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Dobebug rather elegantly explained the gist of it.
As Fitzmar stated, in short, vWD carriers in Dobermans are not considered to be a concern, and even those who are genetically affected, while they may need to be monitored, may not ever become clinically affected.


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