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post #1 of 4 (permalink) Old 05-09-2020, 10:48 AM Thread Starter
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Male DCM1 PDK4 Negative DCM2 Negative
Female DCM1 one copy DCM2 DNA negative

What does the above mean as to the expected puppies?
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post #2 of 4 (permalink) Old 05-09-2020, 11:49 AM
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In terms of whether or not the puppies might have DCM in their future? Not much--studies are still ongoing for both genes--but it's known that some negative dogs develop DCM and some positive dogs never do.

In people a very similar condition has been followed for years and they have now identified at least 28 (the last time I looked it up) genes that are connected to the development of DCM.

So while I think the information is valuable to researchers I don't think you should even think about it being something that can tell you what it means in terms of DCM development in offspring.

What is more important is to research the direct and lateral lineage of the puppies to see how prevalent DCM has been through the generations. That's the kind of thing that is more realistic than trying to guess if or how much the tests for DCM 1 DCM2 might mean.

Good luck though...

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post #3 of 4 (permalink) Old 05-09-2020, 02:53 PM
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Exactly what dobebug said.

Additionally, there are a lot of less than ethical breeders, as well as uneducated breeders, that use the DCM genetic testing as a selling point for their dogs. They tout it as "health testing" while they are not doing annual echoes an holters, which is much more important for giving a picture of current heart health, in addition to actually studying pedigrees and knowing the incidence of DCM in the pedigrees.

All of that said, you still have to understand that DCM can (and does) occur in all lines of Dobermans. That is just a risk you have to take when you own one.
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Richter & Sypha
Glengate's Mountain Fortress CAA ORT L1E L1C NW2 L2V L2I ACT1 RATI SOG WAC
& Sirai's Golden Masquerade ORT L1V L1E L2C L2I NW2 RATI SOG TKN WAC
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post #4 of 4 (permalink) Old 05-09-2020, 03:15 PM
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I will second what MC and Dobebug said. At this point these tests are essentially meaningless in terms of predictability of the disease.
What you will want is to see up to date echos and holters on both parents within the year from the breeding, and a breeder that will keep the annual testing up to date even after the puppies are born.
And in addition to that you want to research the pedigrees. You won't find a pedigree with no DCM at all, but the lower the frequency, and the older the dog at time of death, the better. You want to look for overall good longevity.
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