Ok. So here is the shocker. Marcus genetic test came back negative for the DCM markers. The Vet and the cardiologist that she has been consulting with are a little surprised.
Her next guess, is that he may be turine deficient. He has only eaten Purina Pro Plan Large Breed, which is turbine fortified.
She is going to send blood over to UC Davis to have it tested for turine absorbson.
It is a long shot.
This really shouldn't be a shocker.DCM1 and DCM2 markers only tell you if certain genes which have been associated with cardio in the Doberman are present. They are valuable for further testing of the breed. (In people who have a very similar form of DCM and have had research going on much longer have somewhere around 26 different genes that are known to contribute to DCM in people--AND the researcher all make it clear that this is only the beginning of testing). DCM and both people and Dobermans is not a simple single gene disease--it is polygenetic and I expect many more related genes will be found.
I'm only surprised that the cardiologist was surprised that they found that DCM1 & 2 (and there is some very new information that looks as if DCM 2 may not be a separate gene at all but a modifier of DCM 1). Were both the test for DCM 1 and DCM 2 (and they are either homozygous for DCM1 or heterozygous for DCM1 or negative for DCM1--and at present it looks as if they may have to go back to the drawing board on relationship of DCM2 to DCM1.
It is known that dogs negative for DCM 1 can get DCM and those who are homozygous (have two positive genes) for DCM 1 are sometimes free of cardio.
This is what we've tried to make clear--that testing for DCM 1 and 2 is not any sort of guarantee that a dog of a breed where DCM is generally caused genetically will or will not end up with DCM.
While it is possible that Dobermans who are regarded as one of the genetically at risk for DCM breeds might also be taurine deficient. This is not as likely as in breeds where they found that taurine deficiency (and often when the dog was being fed grain free foods) was the cause and in those cases it appears that, that kind of diet related DCM is reversible.
Have you heard from the cardiologist that he/she was surprised at this--the cardiologists I have dealt with have always been careful to explain the differences between genetic based DCM and dietary DCM.
Let us know what the test results show--there have been an occasional Doberman who was taurine difficient but that is not generally the cause of DCM in the breed.