But again the scientific record has stated that several genes are associated with the disease so one would have to wonder if the test is really that accurate for North American lines as well. Can anyone provide more information on the test mentioned briefly and its accuracy? If as a breeder you incorporate European lines into your breeding program, does the test no longer work?
Only 2 genes have been identified that can be tested for, and they are currently not really "predictive" of DCM in the sense that testing for them does not tell you whether your dog will develop the disease or not (American OR European).
Dogs can have neither gene, and still get DCM. They can have one gene, and get it. They have have both genes and get it. They have have also have both genes, and NOT get it. We have a VERY complex disease that probably involved many genes with incomplete penetrance. We only have a tiny piece of the puzzle.
Researchers so far have also determined that it seems the genes are different in the North American dogs and the European dogs. Again, since the gene tests at this point are more for research purposes than they are for diagnostic decisions (and, I'm not sure how helpful they are for breeding decisions - I'm not a breeder), I'm not sure it's terribly relevant. Certainly, if I were a breeder of European Dobermans I wouldn't be using the gene tests as a decision maker, but I wouldn't be doing that anyway...
You can find quite a few academic articles on the gene tests if you look for them. One is here and specifically discusses the difference in Euro/American: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380154/
This is a pretty good write up of some early response to the gene testing: http://www.utahdobes.org/dcm_dna_test.htm
And, the forum has a sticky of a bunch of DCM threads, too - go to the top of the health forum to the stickies.
Richter & Sypha
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