| I don't know if this will help any, but a friend sent this to me explaining how the mutation affects the different areas. It is really short, but made sense. So if anything is left out, please add it!
"Melanocytes are concentrated in the skin, in hair follicles, and in the iris and retina of the eye. The group of cells in the fetus which eventually develop into melanocytes, the neural crest cells, are also involved in the development of some important nervous system tissues. These include essential elements of the auditory and visual systems of the brain.
Even seemingly unrelated tissues, such as blood vessel walls, can be affected by lack of pigment. Additionally, the C and P genes are closely linked to other genes, which in some cases are responsible for other essential processes such as liver, kidney, or blood clotting function. Therefore, the syndrome of albinism can incorporate a wide variety of disorders in addition to the obvious loss of fur color.
It's very hard to determine what all the problems that arise are due to Albinism, because the canine genome project is still working on mapping the genome of the Doberman, which also includes the albinos, but we know for certain it affects the above mentioned areas, and the defect can also have problems that have gone unreported." |