I've never had a problem putting it on my dogs. That's what finally licked Leo's sarcoptic mange, after the ivermection didn't work. I do, however, have a couple of cats that get a localized reaction to it.
My vet has quit carrying the canine Revolution, though. They have had too many dogs on it come up positive for heartworm.
CA Speed Queen Leontine Von Washateria
Ilka Of Pear Orchard Cemetery BN RE CA CGC
Last, but by no means least, Lucky Rat Dog CGC, Watchdog Emeritus