Genetic Diversity Testing of the Dobe - How to save the breed! - Doberman Forum : Doberman Breed Dog Forums
Doberman Health If it has to do with your dog and its health post here.

 
LinkBack Thread Tools Display Modes
post #1 of 8 (permalink) Old 03-16-2017, 07:10 AM Thread Starter
Alpha
 
Join Date: Jun 2005
Posts: 4,854
Dogs Name: Rah, Berlin and the Cherrybomb
Titles: too many to list!
Dogs Age: 5.5, 3.5, and baby
Gallery Pics: 0
Visit doberkim's Gallery
Thanks: 492
Thanked 12,282 Times in 2,449 Posts
                     
Exclamation Genetic Diversity Testing of the Dobe - How to save the breed!

I am sharing this here because I think it's important that all doberman owners (of ANY type - foreign, domestic, imports, rescues, BYB, well bred, you name it!) - take part in the study currently underway to determine the genetic diversity of the breed.

Currently the work that has been shared has shown the doberman is THE most inbred breed out there. Our breed experienced two severe bottlenecks during the wars, and our famous "seven sires" and such breeding patterns have left us with dogs who despite varied pedigrees, genetically are as related as siblings (or closer). It is no longer enough to look at COI, etc - we need to know the actual genes the dog has inherited from each parent, and start to consider how we can diversify the breed and attempt to dilute out some of the deleterious genes that are being passed along. The first group had 71 dobermans - VGL currently sit at about 200 dobermans tested, but the more data that is gathered the more info we have at our hands. Information from VGL can then be shared to BetterBred.com, so that this information becomes a searchable database for the fancy to use. There is also a private Facebook group discussing the genetics and diversity.

In looking at genetic diversity, we may be able to identify pockets of diversity left within the breed. Minimally we need to arm ourselves with the data so we can try to ensure there is a doberman alive in the future decades.


https://www.vgl.ucdavis.edu/services...InDoberman.php

Swabs and the test can be purchased from the VGL website. Current pricing is at $50, but will rise to $80 once the phase 2 study has been completed. I have tested both Berlin (passed away) and Cherrybomb and will encourage everyone else I know to submit swabs as well.


Bowie's Here Comes the Boom! UD BN RN WAC CGC
Katwalk Calm Like a Bomb CDX PCDX GN B CD-C CGC
Bowie's Atomic Bomb NW1
ARCHX Bowie's Semper Fidelis v DRU, UD ASCA-CDX CDX-H D-CD RE RL1X RL2X RL3 ATT WAC TT CGC VC FFX-OG
Beja's Bombs Away v Bowie, CD ASCA-CD CD-H BN RN NA NAJ RL1 WAC ATT YTT PTT CGC CHIC#71265
Bowie's Modern Love RN CGC
Forever in my heart


more beatings, less love!
doberkim is offline  
The Following 7 Users Say Thank You to doberkim For This Useful Post:
brw1982 (06-16-2017), Darkevs (03-16-2017), dax0402 (03-18-2017), dobebug (05-28-2017), pear (05-26-2017), prairiefire (05-28-2017), ShelianDobe (03-16-2017)
Advertisement
 
post #2 of 8 (permalink) Old 03-16-2017, 08:12 AM
Big Pup
 
Join Date: Feb 2017
Posts: 21
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit sisu27's Gallery
Thanks: 1
Thanked 16 Times in 8 Posts
 
Perhaps this is a stupid question but is there value in swabbing a dog if its parentage is unknown? I just lost my last one to DCM but my parents have a 10yo female rescue. Is her data of value if we can't do anything with her (spayed 10yo) and we know nothing about where she came from?

I feel like I am missing the bigger picture....I have not had enough coffee yet!
sisu27 is offline  
post #3 of 8 (permalink) Old 03-16-2017, 11:04 AM
Big Dog
 
Join Date: Dec 2016
Posts: 76
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit windamyr1's Gallery
Thanks: 38
Thanked 138 Times in 48 Posts
             
sisu27

your rescue girl does have value in a research project!! It doesn't matter about her pedigree, but at double digits and in good health, her karyotype could help narrow down areas of concern, and areas to look at more in depth that could affect longevity. There is one project that I admit I'm partial to as it is Doberman specific. A private lab (Embark) is working with the Doberman Diversity Project with a long term research goal in mind. You do get a lot of information on your particular dog, some is Doberman specific, some not so much,(they test for all 160 known genetic diseases in dogs) but all genetic profiles are being compiled into research data bases to study where/how/ why Dobes are plagued with so many disorders. It is 150 for the test, but your girl would be a valuable contributor to the ongoing project if you participate with her!

www.dobermandiversityproject.org is the place to go for more information
windamyr1 is offline  
 
post #4 of 8 (permalink) Old 05-26-2017, 05:49 PM
Lil Pup
 
Join Date: May 2017
Posts: 5
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit pear's Gallery
Thanks: 5
Thanked 2 Times in 2 Posts
 
The DDP and UC Davis VGL are two different entities.
I tested with the VGL. They now have around 250 Dobermans from all over the world tested and updated results.
It looks like the Australian Doberman may be a "sub-type" of all other Dobermans. Interesting stuff.
pear is offline  
post #5 of 8 (permalink) Old 05-28-2017, 05:00 AM
Big Dog
 
Join Date: Dec 2016
Posts: 76
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit windamyr1's Gallery
Thanks: 38
Thanked 138 Times in 48 Posts
             
They are two entirely different projects. The test you do through UCDavis measures diversity only. The DDP is a long term research project looking for areas of commonality in disease processes. So many have 'research fatigue' that DDP founders(who are Doberman folks) wanted to offer value for your money as well. Therefore you get a complete picture of your dog's genome, (homozygous and heterozygous across the entire genome) genetic COI(based on your dog's genetic makeup) PDK4, DM, vWD, and color. One test that no one expected to be of value is one that tests for a mutation on the gene that affects the production of ALT(a liver enzyme) turns out a lot of Dobes have at least one copy of the defect, which in itself isn't a terrible problem, but when reading blood labs, it's good to know that your dog may tend to run lower than average numbers as 'normal' for that dog. The founders of the project also felt that breeder tools would be essential, so to that end they've had the scientists and software gurus at Embark putting together a set of tools that should be ready for release in the next couple of weeks. So they are absolutely different projects, with different goals. The biggest difference is in the research aspect. UCDavis is not running any Doberman specific research on the data collected, DDP is, and is willing to share all data with any other group who is looking into Doberman health and longevity. I've participated in both, but in addition to gaining knowledge for myself, I absolutely want to support research into the long term improvement of health and vitality in the breed.
windamyr1 is offline  
The Following User Says Thank You to windamyr1 For This Useful Post:
ShelianDobe (05-28-2017)
post #6 of 8 (permalink) Old 05-28-2017, 09:03 AM
Alpha
 
ShelianDobe's Avatar
 
Join Date: Apr 2009
Posts: 4,498
Location: SW Michigan
Dogs Name: Wheeler, Spock, Fame
Titles: Wheeler - AKC GCH/UKC CH, RO3. Spock - AKC/UKC CH. Fame - AKC/UKC CH.
Dogs Age: Wheeler: 11/13/08 Spock: 07/10/13 Fame: 07/10/13
Gallery Pics: 17
Visit ShelianDobe's Gallery
Thanks: 2,833
Thanked 12,883 Times in 3,293 Posts
Images: 17
                     
I have submitted my gang to VGL and also paid for and submitted the stud dog I am breeding Fame to this year, to VGL as well. I am looking into doing the DDP study as well.

Shelly Wing
AKC GCH/UKC CH, RO3 Lyndobe's Wheel of Fortune, "Wheeler"
AKC UKC CH Windsong's Fortune Hunter v Shelian, "Spock"
AKC UKC CH Windsong's Fame N Fortune v Shelian, "Fame"

ShelianDobe is offline  
The Following User Says Thank You to ShelianDobe For This Useful Post:
brw1982 (06-16-2017)
post #7 of 8 (permalink) Old 05-28-2017, 03:26 PM
Big Dog
 
Join Date: Dec 2016
Posts: 76
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit windamyr1's Gallery
Thanks: 38
Thanked 138 Times in 48 Posts
             
I am looking into doing the DDP study as well.

I hope you choose to participate! I know one thing they're working on in addition to the laundry list of other items<G> is a way to match heart info (holter and/or echo results)to a dog, not necessarily for public consumption, but to track the health of that participating dog, and then hopefully it's offspring and grandoffspring and and and ........ as I said, it is absolutely a long term project, and while the diversity aspect is a plus in my mind, and the breeder tools will be a helpful addition to anyone's toolchest,the research possibilities are what have me most excited about participating. That and it's Doberman only, all the data is on just the one breed, compiled in one place, with the ability to look at the entire genome with the best science we currently have.As fast as the fields of genetics, genomics and epigenetics are progressing, the possibilities for gaining knowledge in the future is mind boggling!
windamyr1 is offline  
post #8 of 8 (permalink) Old 06-15-2017, 09:12 AM
Big Dog
 
Join Date: Dec 2016
Posts: 76
Dogs Name: Tell us your dogs name

Gallery Pics: 0
Visit windamyr1's Gallery
Thanks: 38
Thanked 138 Times in 48 Posts
             
More information on the DobermanDiversityProject
Attached Thumbnails
Click image for larger version

Name:	19204693_10156248298961978_1757199813_o.jpg
Views:	19
Size:	75.7 KB
ID:	102610  

Last edited by windamyr1; 06-15-2017 at 09:23 AM.
windamyr1 is offline  
Advertisement
 
Reply

Quick Reply
Message:
Options

Register Now



In order to be able to post messages on the Doberman Forum : Doberman Breed Dog Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.

User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.

Password:


Confirm Password:
Email Address
Please enter a valid email address for yourself.

Email Address:
OR

Log-in









Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools
Show Printable Version Show Printable Version
Email this Page Email this Page
Display Modes
Linear Mode Linear Mode



Posting Rules  
You may post new threads
You may post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

 
For the best viewing experience please update your browser to Google Chrome